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Nick's avatar

From what I've read, cholesterol repairs cell and tissues. LDL goes from liver to the body, and HDL goes from the body's tissues back to the liver. Too much LDL is bad, as it can oxidize and the body won't process it properly. It can then damage the endothelium (cells that line our blood & lymphatic vessels). I haven't found anything to support your statement that the cholesterol specifically repairs the endothelium. But to your point, I have read that high LDL is not an independent predictor of endothelial dysfunction. At this point I don't have any information to go against my current health goals/doctor recommendations: Keep my HDL high (like you, do cardio, play sports). Keep my LDL around 100mg/dl , keep my triglycerides around 150-160. Eat meat, particularly lean meat, vegetables, and fruit/grain carbs in moderation. But what works for me might not work for someone else. Health is very individual and blanket statements for the population don't always work, and in some cases are harmful.

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Chris Liss's avatar

I read a book called The Clot Thickens where he describes heart disease as endothelial injury, from high blood glucose, high uric acid, too little nitric oxide for repair, etc. Basically you get a little scrape in there, and it clots like a cut on your skin, and as it gets more scraped by particles that shouldn't be there, eventually it blocks. (According to him). I'm not sure whether cholesterol specifically repairs that damage or is just part of the process. Agree health is mostly indidividual, but I do think there are some things that are bad for everyone like high fructose corn syrup or too much polyunsaturated fat.

Think Triglycerides should be under 100 or so, but most important ratio (I've read) is TG/HDL. Less than 2:1 is the baseline, but 1:1 is ideal.

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